Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090366 | 0.87 | MAPK14 (0.45) | LMNACRHR1NPY5RCNR1CNR2 | |
| SCHEMBL17090002 | 0.87 | KDM1A (0.40) | KDM1ALMNAHTTCRHR1CACNA1H | |
| SCHEMBL13564822 | 0.85 | MEN1 (0.43) | LMNACRHR1NPY5RCNR1CNR2 | |
| SCHEMBL13565594 | 0.84 | CRHR1 (0.36) | CRHR1NPY5RCNR2 | |
| SCHEMBL17090163 | 0.84 | CRHR1 (0.36) | CRHR1NPY5RCNR2 | |
| SCHEMBL17090523 | 0.84 | GRIA4 (0.42) | CRHR1EPHX2NR1H4NPY5RCNR2 | |
| SCHEMBL13565853 | 0.84 | GRIA4 (0.42) | CRHR1EPHX2NR1H4NPY5RCNR2 | |
| SCHEMBL17090417 | 0.84 | LMNA (0.53) | LMNACRHR1EPHX2MAPK14 | |
| SCHEMBL17090193 | 0.84 | ALDH1A1 (0.45) | HTTCRHR1MAPK14 | |
| SCHEMBL13439231 | 0.83 | HPGD (0.38) | CRHR1NPY5RCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |