Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13564735 | 1.00 | LMNA (0.43) | LMNATP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17090296 | 0.89 | POLB (0.41) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13564937 | 0.89 | POLB (0.41) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17090128 | 0.88 | MEN1 (0.43) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13565746 | 0.88 | MEN1 (0.43) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13213210 | 0.86 | ALDH1A1 (0.39) | TP53CYP3A4ALDH1A1HPGDNPY5R | |
| SCHEMBL17090364 | 0.85 | LMNA (0.51) | LMNAMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL13565317 | 0.85 | LMNA (0.51) | LMNAMEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL17090359 | 0.85 | ALDH1A1 (0.39) | LMNAMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL17090109 | 0.85 | ALDH1A1 (0.39) | ALDH1A1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |