Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17089975 | 0.84 | PTPN1 (0.47) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL17090341 | 0.84 | NPY5R (0.49) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL10113460 | 0.84 | LMNA (0.55) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL10113605 | 0.78 | MGLL (0.44) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL13564925 | 0.77 | HDAC1 (0.42) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL13565776 | 0.77 | HDAC1 (0.42) | PKMNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL13565283 | 0.76 | ALDH1A1 (0.50) | PKMLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL13565821 | 0.76 | ALDH1A1 (0.49) | RAB9ALMNAALDH1A1MAPTKMT2A | |
| SCHEMBL11935701 | 0.75 | NPY5R (0.46) | NPY5R | |
| SCHEMBL13564864 | 0.74 | EPHX1 (0.39) | PKMLMNAALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |