Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17089983 | 0.84 | PTPN1 (0.45) | PTPN1MGLLPKMKMT2APOLB | |
| SCHEMBL10113605 | 0.84 | MGLL (0.44) | PTPN1MGLLPKMNPC1RAB9A | |
| SCHEMBL17090338 | 0.84 | PKM (0.48) | PTPN1MGLLPKMNPC1RAB9A | |
| SCHEMBL10113460 | 0.78 | LMNA (0.55) | MGLLPKMNPC1RAB9ALMNA | |
| SCHEMBL17089976 | 0.76 | CA1 (0.50) | LMNAKMT2AHRH4HRH3MAPT | |
| SCHEMBL17090339 | 0.76 | PTPN1 (0.46) | PTPN1MGLLPKMNPC1RAB9A | |
| SCHEMBL23460163 | 0.75 | PTPN1 (0.53) | PTPN1MGLLPKMNPC1RAB9A | |
| SCHEMBL13564771 | 0.73 | S1PR1 (0.51) | LMNAHRH4HRH3SMN1; SMN2CHRM2 | |
| SCHEMBL11934728 | 0.73 | CHRM2 (0.66) | PKMLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL13565330 | 0.73 | SCN8A (0.48) | HRH4HRH3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |