Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090193 | 0.90 | ALDH1A1 (0.45) | MAPK14ALDH1A1CRHR1HPGDRAB9A | |
| SCHEMBL17090417 | 0.88 | LMNA (0.53) | MAPK14ALDH1A1CRHR1LMNACYP1A2 | |
| SCHEMBL13564822 | 0.87 | MEN1 (0.43) | ALDH1A1CRHR1CNR1CNR2LMNA | |
| SCHEMBL17090365 | 0.87 | CRHR1 (0.47) | MAPK14CRHR1PDE4APDE4BPDE4C | |
| SCHEMBL11935140 | 0.87 | CRHR1 (0.47) | MAPK14CRHR1PDE4APDE4BPDE4C | |
| SCHEMBL13438995 | 0.87 | MAPK14 (0.46) | MAPK14ALDH1A1CRHR1PDE4APDE4B | |
| SCHEMBL11935305 | 0.87 | MAPK14 (0.46) | MAPK14ALDH1A1CRHR1PDE4APDE4B | |
| SCHEMBL17090170 | 0.87 | KDM1A (0.39) | MAPK14CRHR1CNR1CNR2LMNA | |
| SCHEMBL13564877 | 0.85 | CRHR1 (0.47) | MAPK14ALDH1A1CRHR1CNR1CNR2 | |
| SCHEMBL13462871 | 0.85 | HPGD (0.38) | ALDH1A1CRHR1CNR1CNR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |