Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDIT3 | P35638 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565262 | 1.00 | DDIT3 (0.49) | DDIT3NAMPTCYP2C9SMN1; SMN2THRB | |
| SCHEMBL13564994 | 0.89 | LMNA (0.46) | DDIT3NAMPTCYP2C9SMN1; SMN2USP2 | |
| SCHEMBL17090474 | 0.89 | LMNA (0.46) | DDIT3NAMPTCYP2C9SMN1; SMN2USP2 | |
| SCHEMBL17090284 | 0.85 | DDIT3 (0.49) | DDIT3NAMPTCYP2C9SMN1; SMN2THRB | |
| SCHEMBL17090480 | 0.84 | MAPT (0.44) | SMN1; SMN2NPC1GAAALDH1A1MAPT | |
| SCHEMBL13105770 | 0.84 | MAPT (0.44) | SMN1; SMN2NPC1GAAALDH1A1MAPT | |
| SCHEMBL17090550 | 0.84 | MAPT (0.44) | SMN1; SMN2NPC1GAAALDH1A1MAPT | |
| SCHEMBL13564992 | 0.84 | MAPT (0.44) | SMN1; SMN2NPC1GAAALDH1A1MAPT | |
| SCHEMBL13565377 | 0.84 | DDIT3 (0.53) | DDIT3NAMPTCYP2C9SMN1; SMN2THRB | |
| SCHEMBL17090503 | 0.82 | ALDH1A1 (0.54) | NAMPTSMN1; SMN2USP2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |