Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709216 | 0.84 | ACHE (0.47) | ACHESCN9ACHRM2CHRM3SIGMAR1 | |
| SCHEMBL1709211 | 0.70 | SCN9A (0.59) | ACHEBACE1SCN9ASIGMAR1LMNA | |
| SCHEMBL1709213 | 0.70 | SCN9A (0.58) | ACHEBACE1SCN9ASIGMAR1LMNA | |
| SCHEMBL10071963 | 0.68 | SCN9A (0.56) | ACHEBACE1SCN9ASIGMAR1LMNA | |
| SCHEMBL1224833 | 0.68 | TSHR (0.70) | ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL9310741 | 0.67 | BACE1 (0.54) | ACHEBACE1CHRM2CHRM3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9310735 | 0.67 | BACE1 (0.54) | ACHEBACE1CHRM2CHRM3SIGMAR1 | |
| SCHEMBL4832242 | 0.66 | CHRM2 (0.56) | ACHEBACE1CHRM2CHRM3SIGMAR1 | |
| SCHEMBL3894897 | 0.66 | OPRL1 (0.73) | CHRM2CHRM3SIGMAR1POLBALDH1A1 | |
| SCHEMBL12203 | 0.66 | CHRM2 (0.55) | ACHEBACE1CHRM2CHRM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |