Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072406 | 0.90 | SCN9A (0.57) | SCN9ANAMPTACHEBACE1ALDH1A1 | |
| SCHEMBL1709213 | 0.84 | SCN9A (0.58) | SCN9ANAMPTACHEBACE1ALDH1A1 | |
| SCHEMBL10071962 | 0.78 | SCN9A (0.57) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL1709211 | 0.75 | SCN9A (0.59) | SCN9ANAMPTACHEBACE1SIGMAR1 | |
| SCHEMBL18860348 | 0.73 | NAMPT (0.48) | SCN9ANAMPTSMN1; SMN2SIGMAR1KCNH2 | |
| SCHEMBL1709247 | 0.73 | SCN9A (0.64) | SCN9ANAMPTALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL1709232 | 0.72 | SCN9A (1.00) | SCN9ANAMPTACHEBACE1ALDH1A1 | |
| SCHEMBL1709234 | 0.72 | SCN9A (0.60) | SCN9ANAMPTACHEBACE1ALDH1A1 | |
| SCHEMBL9566388 | 0.69 | CXCR4 (0.53) | SCN9ANAMPTACHEBACE1CYP3A4 | |
| SCHEMBL1709212 | 0.68 | ACHE (0.45) | SCN9AACHEBACE1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |