Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709212 | 0.84 | ACHE (0.45) | ACHESIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL654066 | 0.67 | CCR3 (0.68) | CCR3SIGMAR1ALDH1A1DRD4DRD2 | |
| SCHEMBL11353029 | 0.66 | ALDH1A1 (0.83) | ACHESIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL16984334 | 0.65 | ACHE (0.51) | ACHESIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL9566402 | 0.65 | OPRL1 (0.48) | SIGMAR1ALDH1A1MEN1KMT2ASCN9A | |
| SCHEMBL1709249 | 0.64 | DRD4 (0.60) | SIGMAR1ALDH1A1KDM4ESCN9ADRD4 | |
| SCHEMBL653218 | 0.64 | CCR3 (1.00) | CCR3SIGMAR1KDM4EMEN1KMT2A | |
| SCHEMBL654214 | 0.64 | CCR3 (0.68) | CCR3SIGMAR1ALDH1A1DRD4DRD2 | |
| SCHEMBL8804601 | 0.64 | ALDH1A1 (0.67) | ACHEALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL12013906 | 0.63 | SIGMAR1 (0.65) | ACHECCR3SIGMAR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |