Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709213 | 0.81 | SCN9A (0.58) | SCN9ASIGMAR1NAMPTKDM4ELMNA | |
| SCHEMBL10071963 | 0.75 | SCN9A (0.56) | SCN9ASIGMAR1NAMPTGAALMNA | |
| SCHEMBL1709232 | 0.74 | SCN9A (1.00) | SCN9ANAMPTGAAPOLBACHE | |
| SCHEMBL10072406 | 0.73 | SCN9A (0.57) | SCN9ASIGMAR1NAMPTPOLBACHE | |
| SCHEMBL1709247 | 0.72 | SCN9A (0.64) | SCN9ASIGMAR1NAMPTHTTMEN1 | |
| SCHEMBL1709234 | 0.72 | SCN9A (0.60) | SCN9ANAMPTKDM4EHTTACHE | |
| SCHEMBL10071962 | 0.71 | SCN9A (0.57) | SCN9ANAMPTACHEBACE1 | |
| SCHEMBL1709212 | 0.70 | ACHE (0.45) | SCN9ASIGMAR1KDM4EGAALMNA | |
| SCHEMBL4216674 | 0.68 | ALDH1A1 (0.50) | SIGMAR1KDM4EGAALMNAPOLB | |
| SCHEMBL20641661 | 0.68 | CHRM4 (0.73) | SCN9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |