SCHEMBL17099758

SCHEMBL17099758

OB(O)c1ccc(OC(F)(F)CF)cc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA2 P00918 6/20 0.45
CA1 P00915 5/20 0.45
ENPP2 Q13822 4/20 0.45
MGLL Q99685 3/20 0.45
LPL P06858 3/20 0.36
LIPG Q9Y5X9 3/20 0.36
TSHR P16473 1/20 0.35
F11 P03951 1/20 0.35
CA4 P22748 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA7 P43166 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CA5B Q9Y2D0 1/20 0.33
ABL1 P00519 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6466370 0.83 MAPT (0.34) TSHR
SCHEMBL147828 0.79 CA2 (0.52) CA2CA1ENPP2MGLLLPL
SCHEMBL1330772 0.79 ENPP2 (0.51) CA2CA1ENPP2MGLLLPL
SCHEMBL3271256 0.78 ESR1 (0.42)
SCHEMBL25968742 0.76 CA2 (0.54) CA2CA1ENPP2MGLLLPL
SCHEMBL6610143 0.74 CA1 (0.48) CA2CA1ENPP2MGLLABL1
SCHEMBL1393204 0.74 CA1 (0.59) CA2CA1ENPP2MGLLABL1
SCHEMBL849890 0.74 CA2 (0.47) CA2CA1ENPP2MGLLLPL
SCHEMBL9586800 0.74 TDP1 (0.42) TSHR
SCHEMBL26464057 0.73 CA2 (0.50) CA2CA1ENPP2MGLLLPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108289457-B Process for preparing antifungal compounds 迈科维亚医药公司 2021-08-06 CN disclosed
EP-3349586-B1 ANTIFUNGAL COMPOUND PROCESS MYCOVIA PHARMACEUTICALS INC (US) 2020-12-02 EP disclosed
US-10836740-B2 Antifungal compound process Mycovia Pharmaceuticals, Inc. (US) 2020-11-17 US disclosed
US-10745378-B2 Antifungal compound process Mycovia Pharmaceuticals, Inc. (US) 2020-08-18 US disclosed
US-10464921-B2 Antifungal compound process Mycovia Pharmaceuticals, Inc. (US) 2019-11-05 US disclosed
US-20190194160-A1 Antifungal Compound Process Mycovia Pharmaceuticals, Inc. 2019-06-27 US disclosed
US-20190161470-A1 Antifungal Compound Process MYCOVIA PHARMACEUTICALS INC (US) 2019-05-30 US disclosed
US-10196375-B2 Antifungal compound process Mycovia Pharmaceuticals, Inc. (US) 2019-02-05 US disclosed
EP-3349586-A1 ANTIFUNGAL COMPOUND PROCESS Mycovia Pharmaceuticals, Inc. (US) 2018-07-25 EP disclosed
US-20170081310-A1 ANTIFUNGAL COMPOUND PROCESS Mycovia Pharmaceuticals, Inc. 2017-03-23 US disclosed
WO-2017049080-A1 ANTIFUNGAL COMPOUND PROCESS VIAMET PHARMACEUTICALS, INC. (US) 2017-03-23 WO disclosed
EP-3119754-A1 ANTIFUNGAL COMPOUND PROCESS Viamet Pharmaceuticals, Inc. (US) 2017-01-25 EP disclosed
WO-2015143142-A1 ANTIFUNGAL COMPOUND PROCESS VIAMET PHARMACEUTICALS, INC. (US) 2015-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10745378-B2 Antifungal compound process ERG28, DPM1, CYP51A1 CA2 3534/4885CA1 4082/4885ENPP2 2713/4885
US-20170081310-A1 ANTIFUNGAL COMPOUND PROCESS ERG28, DPM1, CYP51A1 CA2 3534/4885CA1 4082/4885ENPP2 2713/4885
US-20190194160-A1 Antifungal Compound Process ERG28, CYP51A1, DPM1 CA2 3644/4885CA1 4197/4885ENPP2 2589/4885
US-10836740-B2 Antifungal compound process ERG28, CYP51A1, DPM1 CA2 3652/4885CA1 4210/4885ENPP2 2534/4885
US-20190161470-A1 Antifungal Compound Process ERG28, DPM1, CYP51A1 CA2 3534/4885CA1 4082/4885ENPP2 2713/4885
US-10196375-B2 Antifungal compound process ERG28, DPM1, CYP51A1 CA2 3534/4885CA1 4082/4885ENPP2 2713/4885
US-10464921-B2 Antifungal compound process ERG28, CYP51A1, DPM1 CA2 3644/4885CA1 4197/4885ENPP2 2589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.