Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | BAX | Q07812 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466370 | 0.89 | MAPT (0.34) | MEN1KMT2ALMNASLC6A2SLC6A3 | |
| SCHEMBL8768624 | 0.83 | MEN1 (0.36) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL8768568 | 0.79 | ESR2 (0.39) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL9586800 | 0.78 | TDP1 (0.42) | KDM4EAPP | |
| SCHEMBL17099758 | 0.78 | CA2 (0.45) | — | |
| SCHEMBL2970013 | 0.77 | TSHR (0.38) | LTA4HCYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL9586685 | 0.77 | MAOB (0.43) | MEN1KMT2AAPP | |
| SCHEMBL221511 | 0.77 | MAPT (0.52) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL7561242 | 0.76 | MEN1 (0.37) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL6640496 | 0.75 | ALDH1A1 (0.34) | SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195290-B1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2015-03-11 | — | — | EP | disclosed |
| US-8435549-B2 | Halogen alkoxy spirocyclic tetramic and tetronic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | BAYER CROPSCIENCE AG (DE) | 2010-11-04 | — | — | US | disclosed |
| EP-2195290-A1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-06-16 | — | — | EP | disclosed |
| US-7524882-B2 | PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders | MERCK & CO., INC. (US) | 2009-04-28 | — | — | US | disclosed |
| WO-2009039975-A1 | HALOGEN ALKOXY SPIROCYCLIC TETRAMIC AND TETRONIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-04-02 | — | — | WO | disclosed |
| EP-1539136-B1 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO INC (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1539136-A4 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO INC (US) | 2006-10-18 | — | — | EP | disclosed |
| US-20050228044-A1 | Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders | MERCK SHARP & DOHME CORP. | 2005-10-13 | — | — | US | disclosed |
| EP-1539136-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004010936-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279873-A1 | Halogen Alkoxy Spirocyclic Tetramic and Tetronic Acid Derivatives | KCNA5, KCNH1, KCNQ5 | ESR1 3712/4885ESR2 4294/4885MEN1 4122/4885 |
| US-20050228044-A1 | Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders | PPARD, PPARA, PPARG | ESR1 925/4885ESR2 234/4885MEN1 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.