Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.38 |
| ▸ | CTSD | P07339 | 9/20 | 0.38 |
| ▸ | CTSE | P14091 | 9/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18737337 | 0.90 | BACE1 (0.39) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL18463911 | 0.89 | BACE1 (0.37) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL17526955 | 0.88 | BACE1 (0.41) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL31634286 | 0.82 | ALDH1A1 (0.41) | BACE1CTSDCTSE | |
| SCHEMBL18127454 | 0.82 | BACE1 (0.33) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL23109986 | 0.82 | BACE1 (0.39) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL18123638 | 0.82 | ALDH1A1 (0.39) | — | |
| SCHEMBL31634285 | 0.81 | ALDH1A1 (0.40) | BACE1CTSDCTSEABCB1 | |
| SCHEMBL21843036 | 0.81 | BACE1 (0.36) | BACE1CTSDCTSE | |
| SCHEMBL17920236 | 0.81 | BACE1 (0.33) | BACE1CTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. | 2017-02-02 | — | — | US | disclosed |
| US-9493511-B2 | Cyclosporin analogs | ALLERGAN, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160289271-A1 | Cyclosporins Modified on the MeBmt Sidechain by Heterocyclic Rings | ALLERGAN, INC. | 2016-10-06 | — | — | US | disclosed |
| US-20160200767-A1 | CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED | ALLERGAN, INC. | 2016-07-14 | — | — | US | disclosed |
| US-9266927-B2 | Cyclosporin A analogs | ALLERGAN, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | ALLERGAN, INC. (US) | 2015-03-05 | — | — | US | disclosed |
| US-20140128329-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | ALLERGAN, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20120088734-A1 | Cyclosporin Analogs | ALLERGAN, INC. (US) | 2012-04-12 | — | — | US | disclosed |
| US-7696166-B2 | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080249002-A1 | CYCLOSPORIN ALKYNE ANALOGUES AND THEIR PHARMACEUTICAL USES | AMR TECHNOLOGY, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20070232531-A1 | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders | AMR TECHNOLOGY, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070232532-A1 | Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders | AMR TECHNOLOGY, INC. (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | TSLP, CHP1, PPP3R1 | BACE1 2445/4885CTSD 584/4885CTSE 578/4885 |
| US-20150065433-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BACE1 2709/4885CTSD 504/4885CTSE 607/4885 |
| US-20120088734-A1 | Cyclosporin Analogs | CHP1, TSLP, PPP3R1 | BACE1 2709/4885CTSD 504/4885CTSE 607/4885 |
| US-20170029469-A1 | CYCLOSPORIN ANALOGS | CHP1, TSLP, PPP3R1 | BACE1 2709/4885CTSD 504/4885CTSE 607/4885 |
| US-20140128329-A1 | OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS | PDE6D, PDE6C, UACA | BACE1 4845/4885CTSD 4643/4885CTSE 4407/4885 |
| US-20080249002-A1 | CYCLOSPORIN ALKYNE ANALOGUES AND THEIR PHARMACEUTICAL USES | PPP3R1, CCR7, CHP1 | BACE1 3638/4885CTSD 1934/4885CTSE 1669/4885 |
| US-20070232531-A1 | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders | HAVCR2, MALT1, NFATC1 | BACE1 3345/4885CTSD 1452/4885CTSE 1483/4885 |
| US-20160289271-A1 | Cyclosporins Modified on the MeBmt Sidechain by Heterocyclic Rings | CHP1, UACA, CRYAB | BACE1 2823/4885CTSD 1538/4885CTSE 1248/4885 |
| US-20070232532-A1 | Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders | HAVCR2, MALT1, NFATC1 | BACE1 2551/4885CTSD 1290/4885CTSE 1441/4885 |
| US-20160200767-A1 | CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED | CHP1, PPIB, FKBP1B | BACE1 1786/4885CTSD 917/4885CTSE 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.