Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101690 | 0.88 | CYP19A1 (0.46) | CA1CA2CA9POLBKMT2A | |
| SCHEMBL17101797 | 0.83 | CXCR4 (0.52) | CA1CA2CA9POLBKMT2A | |
| SCHEMBL17101827 | 0.79 | NR3C2 (0.54) | CA1CA2CA9POLBKMT2A | |
| SCHEMBL17101795 | 0.79 | CXCR4 (0.58) | CA1CA2CA9POLBKMT2A | |
| SCHEMBL17101757 | 0.78 | MAPT (0.48) | CA1CA2CA9POLBCYP19A1 | |
| SCHEMBL17101792 | 0.78 | CA12 (0.65) | CA9KMT2ACYP19A1CA12LMNA | |
| SCHEMBL17101704 | 0.78 | ALDH1A1 (0.61) | CA1CA2CA9POLBKMT2A | |
| SCHEMBL17101705 | 0.77 | KMT2A (0.59) | CA9POLBKMT2ACYP19A1KEAP1 | |
| SCHEMBL17101822 | 0.77 | HSD11B1 (0.61) | KMT2ACYP19A1LMNASMN1; SMN2 | |
| SCHEMBL23777908 | 0.77 | CYP19A1 (0.50) | CA1CA2CA9POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |