Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101827 | 0.89 | NR3C2 (0.54) | CXCR4KMT2ANR3C2LMNASMN1; SMN2 | |
| SCHEMBL17101702 | 0.87 | HTT (0.46) | CXCR4KMT2ANR3C2LMNASMN1; SMN2 | |
| SCHEMBL17101682 | 0.83 | LMNA (0.51) | CXCR4KMT2ANR3C2LMNANSD2 | |
| SCHEMBL17101694 | 0.81 | SMN1; SMN2 (0.72) | LMNASMN1; SMN2ALDH1A1NR3C1POLB | |
| SCHEMBL17101699 | 0.80 | LMNA (0.47) | KMT2ANR3C2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17101688 | 0.79 | LMNA (0.51) | NR3C2LMNASMN1; SMN2ALDH1A1NR3C1 | |
| SCHEMBL17101693 | 0.79 | CA1 (0.49) | CXCR4KMT2ALMNASMN1; SMN2CA1 | |
| SCHEMBL17101797 | 0.77 | CXCR4 (0.52) | CXCR4KMT2ASMN1; SMN2CA1CA2 | |
| SCHEMBL17101678 | 0.76 | CA1 (0.45) | CXCR4KMT2ALMNANSD2CA1 | |
| SCHEMBL17101675 | 0.76 | MEP1B (0.52) | KMT2ALMNASMN1; SMN2ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |