Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.52 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101682 | 0.83 | LMNA (0.51) | LMNACA12CA9NR3C2KEAP1 | |
| SCHEMBL17101701 | 0.83 | NR3C2 (0.48) | LMNACA12CA9NR3C2TP53 | |
| SCHEMBL5167263 | 0.80 | SMN1; SMN2 (0.56) | LMNACA12CA9ALDH1A1L3MBTL1 | |
| SCHEMBL17101697 | 0.80 | NPY1R (0.51) | LMNACA12CA9ALDH1A1KEAP1 | |
| SCHEMBL17101699 | 0.77 | LMNA (0.47) | LMNANR3C2TP53ALDH1A1MCL1 | |
| SCHEMBL17101815 | 0.77 | LMNA (0.43) | LMNACA12CA9KEAP1L3MBTL1 | |
| SCHEMBL17101704 | 0.77 | ALDH1A1 (0.61) | LMNAHSD11B1CA12CA9TP53 | |
| SCHEMBL17101822 | 0.76 | HSD11B1 (0.61) | LMNAHSD11B1TP53ALDH1A1L3MBTL1 | |
| SCHEMBL5651347 | 0.76 | KEAP1 (0.74) | LMNASLC12A2SLC12A5CA12CA9 | |
| SCHEMBL23603320 | 0.74 | LMNA (0.56) | LMNASLC12A2SLC12A5HSD11B1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |