Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101678 | 0.84 | CA1 (0.45) | LMNACA12CA9NSD2KEAP1 | |
| SCHEMBL17101795 | 0.83 | CXCR4 (0.58) | LMNACA9NR3C2NSD2KMT2A | |
| SCHEMBL17101827 | 0.83 | NR3C2 (0.54) | LMNACA9NR3C2NSD2KMT2A | |
| SCHEMBL17101701 | 0.83 | NR3C2 (0.48) | LMNACA12CA9NR3C2KEAP1 | |
| SCHEMBL17101772 | 0.83 | LMNA (0.52) | LMNACA12CA9NR3C2KEAP1 | |
| SCHEMBL17101697 | 0.82 | NPY1R (0.51) | LMNACA12CA9NSD2KEAP1 | |
| SCHEMBL17101699 | 0.82 | LMNA (0.47) | LMNANR3C2KMT2AMEN1GAA | |
| SCHEMBL17101702 | 0.81 | HTT (0.46) | LMNANR3C2KMT2ACXCR4TSHR | |
| SCHEMBL17101688 | 0.81 | LMNA (0.51) | LMNANR3C2TSHRL3MBTL1 | |
| SCHEMBL17101691 | 0.81 | TRPV1 (0.40) | LMNAGBA1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |