Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722752 | 0.88 | HTR6 (0.46) | MGLLMAPK1PNMTNR1H2NR1H3 | |
| SCHEMBL3839356 | 0.81 | LPL (0.46) | LPLLIPGCYP2D6CNR1CNR2 | |
| SCHEMBL3837696 | 0.79 | LPL (0.45) | LPLLIPGCYP2D6CNR1CNR2 | |
| SCHEMBL1710601 | 0.78 | LMNA (0.43) | FDFT1 | |
| SCHEMBL10180981 | 0.77 | PSIP1 (0.52) | KAT6ALPLLIPGCNR1CNR2 | |
| SCHEMBL3837739 | 0.77 | LPL (0.42) | LPLLIPGMAPK1CYP2D6PPARG | |
| SCHEMBL28202089 | 0.76 | CA2 (0.48) | MAPK1HTR6 | |
| SCHEMBL10235643 | 0.75 | LPL (0.50) | LPLLIPGCYP2D6CNR1CNR2 | |
| SCHEMBL10181083 | 0.75 | PSIP1 (0.48) | LPLLIPGCNR2PPARGPPARA | |
| SCHEMBL1710742 | 0.74 | HTR6 (0.51) | LPLLIPGHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |