Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710643 | 1.00 | CA2 (0.34) | CA2CA1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL1710491 | 1.00 | CA2 (0.34) | CA2CA1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL1710687 | 0.95 | CA2 (0.36) | CA2CA1HSD11B1 | |
| SCHEMBL1710903 | 0.94 | HSD11B1 (0.34) | CA2CA1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL1710684 | 0.93 | ALDH1A1 (0.41) | CA2KDM4EALDH1A1 | |
| SCHEMBL3385934 | 0.93 | ALDH1A1 (0.41) | CA2KDM4EALDH1A1 | |
| SCHEMBL3385936 | 0.93 | ALDH1A1 (0.41) | CA2KDM4EALDH1A1 | |
| SCHEMBL1710595 | 0.91 | KDM4E (0.36) | CA2CA1KDM4EALDH1A1 | |
| SCHEMBL1710755 | 0.91 | KDM4E (0.36) | CA2CA1KDM4EALDH1A1 | |
| SCHEMBL1710593 | 0.91 | KDM4E (0.36) | CA2CA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20100093865-A1 | SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093865-A1 | SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ALDH1A2, MPST, CLN6 | CA2 1943/4885CA1 4504/4885HSD11B1 1087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.