Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703323 | 0.85 | ADORA2A (0.39) | GABRB2GABRA2HSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL23920002 | 0.85 | HRH4 (0.40) | GABRB2GABRA2KDM4EMAPTGAA | |
| SCHEMBL18861629 | 0.85 | HSP90AA1 (0.43) | GABRB2GABRA2HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL6122122 | 0.85 | PDE2A (0.38) | GABRB2GABRA2HSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL30946587 | 0.85 | PDE2A (0.38) | GABRB2GABRA2HSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL15927343 | 0.84 | GABRA2 (0.49) | GABRB2GABRA2GABRA1 | |
| SCHEMBL24027425 | 0.82 | ADORA2A (0.33) | GABRB2GABRA2HSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL24027518 | 0.82 | GABRA2 (0.35) | GABRB2GABRA2HSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL2608422 | 0.80 | GABRA1 (0.42) | GABRB2HSP90AA1KDM4EMAPTGAA | |
| SCHEMBL12553824 | 0.79 | KDM4E (0.42) | GABRB2GABRA2HSP90AA1HSP90AB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | GABRB2 346/4885GABRA2 535/4885HSP90AA1 2808/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | GABRB2 426/4885GABRA2 555/4885HSP90AA1 3054/4885 |
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | GABRB2 154/4885GABRA2 64/4885HSP90AA1 4381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.