Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.41 |
| ▸ | FABP7 | O15540 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16678782 | 0.99 | KMT2A (0.48) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL14759878 | 0.88 | KMT2A (0.60) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL14237194 | 0.88 | KMT2A (0.51) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL7705059 | 0.88 | KMT2A (0.51) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL3427659 | 0.88 | KMT2A (0.51) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL2116826 | 0.86 | KMT2A (0.49) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL7132450 | 0.84 | KMT2A (0.54) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL28749692 | 0.84 | KMT2A (0.54) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL3623157 | 0.83 | KMT2A (0.55) | KMT2AFABP5FABP7CA1CA2 | |
| SCHEMBL2401694 | 0.82 | KMT2A (0.70) | KMT2AFABP5FABP7CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240209432-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | Roche Sequencing Solutions, Inc. (US) | 2024-06-27 | — | — | US | disclosed |
| EP-4303314-A2 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | F. Hoffmann-La Roche AG (CH) | 2024-01-10 | — | — | EP | disclosed |
| US-11739378-B2 | Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection | Roche Sequencing Solutions, Inc. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230010193-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-01-12 | — | — | US | disclosed |
| US-11396677-B2 | Chemical methods for producing tagged nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-07-26 | — | — | US | disclosed |
| EP-3122759-B1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | UNIV COLUMBIA (US) | 2022-06-01 | — | — | EP | disclosed |
| US-20220090189-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | Roche Sequencing Solutions, Inc. (US) | 2022-03-24 | — | — | US | disclosed |
| CN-106715453-B | Chemical process for producing tagged nucleotides | 哥伦比亚大学董事会 | 2021-04-30 | — | — | CN | disclosed |
| US-10975426-B2 | Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection | Roche Sequencing Solutions, Inc. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190276887-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-09-12 | — | — | US | disclosed |
| US-10240195-B2 | Chemical methods for producing tagged nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-26 | — | — | US | disclosed |
| US-20190002968-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | Roche Sequencing Solutions, Inc. | 2019-01-03 | — | — | US | disclosed |
| EP-3347366-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | H. Hoffnabb-La Roche Ag (CH) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017042038-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2017-03-16 | — | — | WO | disclosed |
| EP-3122759-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | The Trustees of Columbia University in the City of New York (US) | 2017-02-01 | — | — | EP | disclosed |
| US-20150368710-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-12-24 | — | — | US | disclosed |
| WO-2015148402-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK (US) | 2015-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11739378-B2 | Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection | NPPA, ANPEP, TENT4A | KMT2A 3667/4885FABP5 1797/4885FABP7 1315/4885 |
| US-20220090189-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | NPPA, ANPEP, TENT4A | KMT2A 3667/4885FABP5 1797/4885FABP7 1315/4885 |
| US-20150368710-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | NT5C3B, NCL, NUDT1 | KMT2A 1493/4885FABP5 2749/4885FABP7 3005/4885 |
| US-20230010193-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | NT5C3B, NCL, NUDT1 | KMT2A 1493/4885FABP5 2749/4885FABP7 3005/4885 |
| US-20190002968-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | NPPA, ANPEP, TENT4A | KMT2A 3667/4885FABP5 1797/4885FABP7 1315/4885 |
| US-20240209432-A1 | POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION | NPPA, ANPEP, TENT4A | KMT2A 3667/4885FABP5 1797/4885FABP7 1315/4885 |
| US-10975426-B2 | Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection | NPPA, ANPEP, TENT4A | KMT2A 3667/4885FABP5 1797/4885FABP7 1315/4885 |
| US-11396677-B2 | Chemical methods for producing tagged nucleotides | NT5C3B, NCL, NUDT1 | KMT2A 1493/4885FABP5 2749/4885FABP7 3005/4885 |
| US-20190276887-A1 | CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES | NT5C3B, NCL, NUDT1 | KMT2A 1493/4885FABP5 2749/4885FABP7 3005/4885 |
| US-10240195-B2 | Chemical methods for producing tagged nucleotides | NT5C3B, NCL, NUDT1 | KMT2A 1493/4885FABP5 2749/4885FABP7 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.