Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.36 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.36 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743130 | 0.87 | LNPEP (0.39) | LNPEPLRRK2SIK1SIK2SIK3 | |
| SCHEMBL15710158 | 0.85 | SIK1 (0.40) | LNPEPLRRK2SIK1SIK2SIK3 | |
| SCHEMBL17115671 | 0.81 | CHRM4 (0.37) | LNPEPLRRK2ACACBAOC3 | |
| SCHEMBL15752631 | 0.79 | LNPEP (0.37) | LNPEPACACBPROKR1 | |
| SCHEMBL17115679 | 0.79 | AOC3 (0.39) | LRRK2AOC3 | |
| SCHEMBL30489402 | 0.74 | OPRM1 (0.39) | LRRK2CYP2C9PROKR1 | |
| SCHEMBL17115658 | 0.73 | POLB (0.44) | — | |
| SCHEMBL17115637 | 0.70 | AOC3 (0.38) | ACACBAOC3 | |
| SCHEMBL18861468 | 0.70 | GLS (0.47) | PROKR1MAP3K12GSK3B | |
| SCHEMBL31107041 | 0.69 | LRRK2 (0.35) | LRRK2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143340-A1 | COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |