Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30489430 | 0.79 | USP30 (0.47) | SCN10ATSHRCASP1HSD17B10 | |
| SCHEMBL30489405 | 0.76 | OPRM1 (0.39) | OPRM1ADORA3TSHRMC4RADRA1A | |
| SCHEMBL15511394 | 0.75 | HRH4 (0.54) | HSD17B10 | |
| SCHEMBL27691156 | 0.75 | HRH4 (0.50) | CYP2C9SCN9A | |
| SCHEMBL15743130 | 0.75 | LNPEP (0.39) | LRRK2PROKR1 | |
| SCHEMBL17115674 | 0.74 | LNPEP (0.38) | LRRK2CYP2C9PROKR1 | |
| SCHEMBL31107041 | 0.73 | LRRK2 (0.35) | LRRK2PROKR1 | |
| SCHEMBL26684427 | 0.73 | ACACB (0.42) | OPRM1NR1H2NR1H3 | |
| SCHEMBL31565292 | 0.72 | HTT (0.52) | — | |
| SCHEMBL15289493 | 0.72 | CDK1 (0.50) | OPRM1LRRK2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |