SCHEMBL17124304

SCHEMBL17124304

COc1ccc(C(c2ccc(OC(=O)CC(C)=O)cc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.42
MAPT P10636 3/20 0.42
ALDH1A1 P00352 2/20 0.42
HSD17B10 Q99714 2/20 0.42
HTT P42858 2/20 0.42
KMT2A Q03164 2/20 0.42
GAA P10253 3/20 0.42
ALOX15 P16050 1/20 0.42
APEX1 P27695 1/20 0.42
MAPK1 P28482 1/20 0.42
RECQL P46063 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
PDK1 Q15118 1/20 0.40
PDK2 Q15119 1/20 0.40
PDK3 Q15120 1/20 0.40
PDK4 Q16654 1/20 0.40
HSD11B1 P28845 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10001296 0.84 LMNA (0.49) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL13620116 0.83 LMNA (0.47) LMNAMAPTALDH1A1HSD17B10KMT2A
SCHEMBL12722262 0.80 KMT2A (0.46) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL14580011 0.80 LMNA (0.52) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL15001277 0.79 ALDH1A1 (0.46) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL20312049 0.78 ELANE (0.47) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL10112762 0.78 CA1 (0.52) MAPTALDH1A1KMT2AGAAMAPK1
SCHEMBL2616610 0.78 CA1 (0.52) MAPTALDH1A1KMT2AGAAMAPK1
SCHEMBL12890380 0.77 SAE1 (0.57) LMNAMAPTALDH1A1HSD17B10HTT
SCHEMBL2703212 0.77 ALDH1A1 (0.47) LMNAMAPTALDH1A1HSD17B10HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9651879-B2 Electrophotographic photosensitive member, method of producing the electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-05-16 US disclosed
US-9507283-B2 Electrophotographic photosensitive member, method of producing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-11-29 US disclosed
US-20160238957-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING THE ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-08-18 US disclosed
US-20160202621-A1 TONER AND IMAGE FORMING METHOD CANON KABUSHIKI KAISHA (JP) 2016-07-14 US disclosed
US-9274442-B2 Electrophotographic image forming apparatus having charge transport layer with matrix-domain structure and charging member having concavity and protrusion CANON KABUSHIKI KAISHA (JP) 2016-03-01 US disclosed
US-9235144-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-01-12 US disclosed
US-20150277248-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
US-20150277244-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed