Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 6/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.42 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185371 | 0.90 | KMT2A (0.49) | STIM1ORAI1MEN1NPC1RAB9A | |
| SCHEMBL17125361 | 0.89 | KMT2A (0.52) | RXRARXRBMEN1NPC1RAB9A | |
| SCHEMBL17125386 | 0.89 | MEN1 (0.47) | STIM1ORAI1MEN1NPC1RAB9A | |
| SCHEMBL17125362 | 0.87 | RXRA (0.45) | RXRARXRBMEN1NPC1RAB9A | |
| SCHEMBL17125348 | 0.85 | STIM1 (0.46) | RXRARXRBSTIM1ORAI1MEN1 | |
| SCHEMBL181928 | 0.84 | HTT (0.52) | STIM1ORAI1MEN1KMT2AKMO | |
| SCHEMBL181876 | 0.84 | KMT2A (0.51) | STIM1ORAI1MEN1KMT2AKMO | |
| SCHEMBL182162 | 0.83 | KMO (0.53) | STIM1ORAI1NPC1RAB9AKMO | |
| SCHEMBL2710440 | 0.83 | ALDH1A1 (0.49) | RXRARXRBMEN1NPC1RAB9A | |
| SCHEMBL182299 | 0.83 | AURKA (0.53) | STIM1ORAI1KMORPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | PTC THERAPEUTICS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | UPF1, RNMT, VHL | RXRA 3460/4885RXRB 3436/4885STIM1 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.