Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082667 | 0.89 | — | — | |
| SCHEMBL28258314 | 0.80 | KMT2A (0.56) | NAPRTRAB9ANPC1PKMLMNA | |
| SCHEMBL28179572 | 0.78 | KMT2A (0.54) | NAPRTRAB9ANPC1PKMLMNA | |
| SCHEMBL27714809 | 0.76 | RAB9A (0.59) | RAB9ANPC1PKMLMNAHIF1A | |
| SCHEMBL10503692 | 0.74 | SMN1; SMN2 (0.47) | NAPRTRAB9ANPC1PKMLMNA | |
| Sulfuric Acid SCHEMBL10941663 | 0.73 | IDO1 (0.74) | NAPRTPKMLMNAMEN1KMT2A | |
| Sulfuric Acid SCHEMBL18396660 | 0.72 | NAPRT (0.57) | NAPRTRAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL790282 | 0.72 | NAMPT (0.65) | LMNAMEN1KMT2ANAMPTTP53 | |
| SCHEMBL7545177 | 0.72 | CA1 (0.57) | LMNAMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL6490312 | 0.72 | GAA (0.55) | RAB9ANPC1PKMLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343976-A1 | METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS | Acorda Therapeutics, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010030755-A1 | METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS | ACORDA THERAPEUTICS, INC. (US) | 2010-03-18 | — | — | WO | disclosed |