Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | SI | P14410 | 5/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | KIF20A | O95235 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HAT1 | O14929 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713809 | 1.00 | CYP19A1 (0.41) | CYP19A1MGAMGAASIMGAM2 | |
| SCHEMBL2072816 | 0.79 | MTNR1A (0.43) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL1714010 | 0.77 | MTNR1A (0.46) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL1714014 | 0.77 | MTNR1A (0.46) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL1713731 | 0.77 | MGAM (0.45) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL2072930 | 0.76 | MTNR1A (0.43) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL3151911 | 0.72 | SLC6A2 (0.44) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL1714319 | 0.71 | MTNR1A (0.44) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL1714318 | 0.71 | MTNR1A (0.44) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL13451628 | 0.71 | MTNR1A (0.42) | MGAMGAASIMGAM2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | disclosed |
| EP-1957454-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | disclosed |
| WO-2007062994-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | TPH1, TPH2, HTR1A | CYP19A1 108/4885MGAM 3927/4885GAA 4667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.