Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.47 |
| ▸ | CNR2 | P34972 | 10/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17142066 | 0.88 | CNR2 (0.45) | CNR1CNR2 | |
| SCHEMBL21065341 | 0.83 | CNR2 (0.56) | CNR1CNR2 | |
| SCHEMBL411937 | 0.82 | CNR1 (0.52) | CNR1CNR2KMO | |
| SCHEMBL14152299 | 0.81 | CNR2 (0.58) | CNR2KMO | |
| SCHEMBL411043 | 0.80 | CNR2 (0.66) | CNR1CNR2KMO | |
| SCHEMBL17142079 | 0.80 | CNR2 (0.68) | CNR1CNR2 | |
| SCHEMBL2116976 | 0.79 | CNR1 (0.66) | CNR1CNR2KMO | |
| SCHEMBL17142116 | 0.78 | CNR2 (0.51) | CNR1CNR2 | |
| SCHEMBL17142039 | 0.77 | KMO (0.49) | CNR2KMO | |
| SCHEMBL30680327 | 0.77 | CNR2 (0.66) | CNR1CNR2KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111170938-A | 5, 6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists | 豪夫迈·罗氏有限公司 | 2020-05-19 | — | — | CN | disclosed |
| EP-3126349-B1 | 5,6-DISUBSTITUTED PYRIDINE-2-CARBOXAMIDES AS CANNABINOID RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2019-06-26 | — | — | EP | disclosed |
| EP-3126349-B1 | 5,6-DISUBSTITUTED PYRIDINE-2-CARBOXAMIDES AS CANNABINOID RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2019-06-26 | — | — | EP | disclosed |
| US-20180327360-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-11-15 | — | — | US | disclosed |
| EP-3126349-A1 | 5,6-DISUBSTITUTED PYRIDINE-2-CARBOXAMIDES AS CANNABINOID RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2017-02-08 | — | — | EP | disclosed |
| US-20160376237-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160376237-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2016-12-29 | — | — | US | disclosed |
| WO-2015150438-A1 | 5,6-DISUBSTITUTED PYRIDINE-2-CARBOXAMIDES AS CANNABINOID RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | disclosed |
| WO-2015150438-A1 | 5,6-DISUBSTITUTED PYRIDINE-2-CARBOXAMIDES AS CANNABINOID RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376237-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | CNR1 12/4885CNR2 19/4885KMO 1367/4885 |
| US-20180327360-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS4, NDUFV1 | CNR1 12/4885CNR2 19/4885KMO 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.