Cloxyquin

Cloxyquin

SCHEMBL1714836

[Be+2].[O-]c1ccc(Cl)c2cccnc12.[O-]c1ccc(Cl)c2cccnc12

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.61
MAPT P10636 5/20 0.61
LMNA P02545 4/20 0.61
HSP90AA1 P07900 4/20 0.61
METAP2 P50579 2/20 0.61
METAP1 P53582 2/20 0.61
BRD4 O60885 1/20 0.61
ALDH1A1 P00352 7/20 0.57
L3MBTL1 Q9Y468 3/20 0.52
CCR1 P32246 1/20 0.52
CCR8 P51685 1/20 0.52
ALOX15 P16050 3/20 0.51
CYP1A2 P05177 2/20 0.51
HIF1A Q16665 2/20 0.51
HSD17B10 Q99714 1/20 0.51
TDP1 Q9NUW8 5/20 0.50
KMT2A Q03164 5/20 0.50
MEN1 O00255 4/20 0.50
HTT P42858 4/20 0.50
SMN1; SMN2 Q16637 4/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cloxyquin SCHEMBL1714863 0.98 KDM4E (0.59) KDM4EMAPTLMNAHSP90AA1METAP2
Cloxyquin SCHEMBL1193743 0.98 KDM4E (0.59) KDM4EMAPTLMNAHSP90AA1METAP2
Cloxyquin SCHEMBL1714880 0.98 KDM4E (0.59) KDM4EMAPTLMNAHSP90AA1METAP2
Cloxyquin SCHEMBL1714431 0.98 KDM4E (0.59) KDM4EMAPTLMNAHSP90AA1METAP2
Cloxyquin SCHEMBL1194112 0.98 KDM4E (0.59) KDM4EMAPTLMNAHSP90AA1METAP2
SCHEMBL196536 0.83 KDM4E (0.70) KDM4EMAPTLMNAHSP90AA1METAP2
SCHEMBL21081235 0.79 KDM4E (0.66) KDM4EMAPTLMNAHSP90AA1METAP2
SCHEMBL2056205 0.76 KDM4E (0.61) KDM4EMAPTLMNAHSP90AA1METAP2
Cloxyquin SCHEMBL115838 0.76 KDM4E (1.00) KDM4EMAPTLMNAHSP90AA1METAP2
SCHEMBL10159159 0.76 KDM4E (0.61) KDM4EMAPTLMNAHSP90AA1METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1486549-B1 ORGANIC ELECTROLUMINESCENT ELEMENT TOYOTA JIDOSHOKKI KK (JP) 2012-01-11 EP disclosed
EP-1755362-B1 ORGANIC EL DEVICE TOYOTA JIDOSHOKKI KK (JP) 2011-07-20 EP disclosed
US-7854998-B2 Organic EL devices KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2010-12-21 US disclosed
EP-1489154-B1 ORGANIC ELECTROLUMINESCENCE DEVICE TOYOTA JIDOSHOKKI KK (JP) 2009-05-13 EP disclosed
US-7521567-B2 Amine compound and uses thereof KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2009-04-21 US disclosed
US-20080290788-A1 Organic el Devices KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2008-11-27 US disclosed
US-7419727-B2 Organic electroluminescent device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2008-09-02 US disclosed
US-7338720-B2 Organic electroluminescent element KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2008-03-04 US disclosed
US-7252892-B2 Organic electroluminescence device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2007-08-07 US disclosed
EP-1755362-A1 ORGANIC EL DEVICE KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2007-02-21 EP disclosed
US-20070018568-A1 Organic electroluminescent device KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2007-01-25 US disclosed
US-20060228577-A1 Organic electroluminescent device KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2006-10-12 US disclosed
US-20060226421-A1 Amine compound and uses thereof KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KENKYUJO (JP) 2006-10-12 US disclosed
US-20060192473-A1 Organic electroluminescent device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2006-08-31 US disclosed
EP-1599074-A1 ORGANIC ELECTROLUMINESCENT DEVICE Kabushiki Kaisha Toyota Jidoshokki (JP) 2005-11-23 EP disclosed
EP-1560469-A1 ORGANIC ELECTROLUMINESCENT DEVICE Kabushiki Kaisha Toyota Jidoshokki (JP) 2005-08-03 EP disclosed
US-20050089713-A1 Organic electroluminescent element KABUSHIKI KAISHA TOYOTA JIDOSHOKKI (JP) 2005-04-28 US disclosed
US-20050084707-A1 Organic electroluminescence device KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 2005-04-21 US disclosed
EP-1489154-A1 ORGANIC ELECTROLUMINESCENCE DEVICE Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-12-22 EP disclosed
EP-1486549-A1 ORGANIC ELECTROLUMINESCENT ELEMENT Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060226421-A1 Amine compound and uses thereof PNMT, TYR, PAM KDM4E 260/4885MAPT 530/4885LMNA 586/4885
US-20050084707-A1 Organic electroluminescence device ELAVL1, SELE, CELF2 KDM4E 2019/4885MAPT 3064/4885LMNA 1262/4885
US-20050089713-A1 Organic electroluminescent element SOD3, CELF2, SOD1 KDM4E 2269/4885MAPT 3933/4885LMNA 952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.