Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | GCKR | Q14397 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18417644 | 0.88 | ALDH1A1 (0.34) | ALDH1A1PLAUSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL17173649 | 0.82 | ALDH1A1 (0.39) | ALDH1A1PLAUSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL12871592 | 0.82 | ALDH1A1 (0.50) | ALDH1A1PLAUSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL18843472 | 0.82 | ALDH1A1 (0.32) | ALDH1A1PLAUSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL2415072 | 0.82 | ALDH1A1 (0.42) | ALDH1A1PLAUCYP11B2CYP11B1MAOB | |
| SCHEMBL17177782 | 0.80 | CHRNB2 (0.38) | ALDH1A1PLAUCYP11B2CYP11B1MAOB | |
| SCHEMBL370663 | 0.78 | HSD17B10 (0.36) | ALDH1A1SMN1; SMN2KDM4ECYP2C19 | |
| SCHEMBL10204664 | 0.77 | LMNA (0.39) | ALDH1A1PLAUSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL21419053 | 0.76 | KMT2A (0.46) | ALDH1A1CYP11B2MAOBSMN1; SMN2MAPK1 | |
| SCHEMBL17196427 | 0.76 | L3MBTL1 (0.42) | ALDH1A1MAOBKMT2ACYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828285-B2 | Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors | CHEMOCENTRYX, INC. (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190300526-A1 | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS | CHEMOCENTRYX, INC. | 2019-10-03 | — | — | US | disclosed |
| US-20190192491-A1 | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS | CHEMOCENTRYX, INC. | 2019-06-27 | — | — | US | disclosed |
| US-9926302-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9879000-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-01-30 | — | — | US | disclosed |
| US-20170121314-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2017-05-04 | — | — | US | disclosed |
| US-20170121314-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2017-05-04 | — | — | US | disclosed |
| US-20150291572-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192491-A1 | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS | C5AR1, C5AR2, C3AR1 | ALDH1A1 3050/4885PLAU 399/4885CYP11B2 2482/4885 |
| US-20170121314-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | TRPV1, CACNA1B, CACNA1C | ALDH1A1 2565/4885PLAU 4811/4885CYP11B2 1215/4885 |
| US-20150291572-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | TRPV1, CACNA1B, CACNA1C | ALDH1A1 2565/4885PLAU 4811/4885CYP11B2 1215/4885 |
| US-20190300526-A1 | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS | C5AR2, C5AR1, C3AR1 | ALDH1A1 2620/4885PLAU 496/4885CYP11B2 1304/4885 |
| US-10828285-B2 | Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors | C5AR1, C5AR2, C3AR1 | ALDH1A1 3050/4885PLAU 399/4885CYP11B2 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.