Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 2/20 | 0.44 |
| ▸ | CHRNG | P07510 | 2/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.44 |
| ▸ | CHRND | Q07001 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | QRFPR | Q96P65 | 5/20 | 0.43 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16485173 | 0.88 | CHRNB2 (0.48) | CHRNA1CHRNGCHRNB1CHRNDTACR2 | |
| SCHEMBL16485412 | 0.88 | CHRNA1 (0.42) | CHRNA1CHRNGCHRNB1CHRNDMMP2 | |
| SCHEMBL21153677 | 0.84 | ALDH1A1 (0.42) | — | |
| SCHEMBL18909647 | 0.83 | ITGB3 (0.49) | CHRNA1CHRNGCHRNB1CHRNDITGB3 | |
| SCHEMBL30805368 | 0.82 | AKT1 (0.43) | CHRNA1CHRNGCHRNB1CHRNDQRFPR | |
| SCHEMBL27154226 | 0.81 | CHRNA1 (0.51) | CHRNA1CHRNGCHRNB1CHRNDTACR2 | |
| SCHEMBL27150500 | 0.81 | CHRNA1 (0.51) | CHRNA1CHRNGCHRNB1CHRNDTACR2 | |
| SCHEMBL21152554 | 0.80 | ACE (0.40) | TACR2 | |
| SCHEMBL16330787 | 0.79 | CHRNA1 (0.45) | CHRNA1CHRNGCHRNB1CHRNDTACR2 | |
| SCHEMBL20041101 | 0.79 | AKT1 (0.45) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015155998-A1 | ANTI-HER3 ANTIBODY-DRUG CONJUGATE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-15 | — | — | WO | disclosed |