SCHEMBL1705359

SCHEMBL1705359

CC(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GNPAT O15228 2/20 0.50
SIRT5 Q9NXA8 2/20 0.47
SIRT6 Q8N6T7 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
C3AR1 Q16581 1/20 0.43
FOLH1 Q04609 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.41
NPY4R P50391 9/20 0.41
NPY1R P25929 6/20 0.41
NPY5R Q15761 4/20 0.41
NPY2R P49146 3/20 0.41
ALB P02768 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31094973 0.96 GNPAT (0.53) GNPATSIRT5SIRT6SIRT1FOLH1
SCHEMBL29655002 0.96 GNPAT (0.53) GNPATSIRT5SIRT6SIRT1FOLH1
SCHEMBL29454444 0.96 GNPAT (0.53) GNPATSIRT5SIRT6SIRT1FOLH1
SCHEMBL1718474 0.96 GNPAT (0.53) GNPATSIRT5SIRT6SIRT1FOLH1
SCHEMBL6026003 0.90 FOLH1 (0.49) GNPATSIRT5SIRT6SIRT1C3AR1
SCHEMBL446929 0.90 FOLH1 (0.49) GNPATSIRT5SIRT6SIRT1C3AR1
SCHEMBL468901 0.90 FOLH1 (0.49) GNPATSIRT5SIRT6SIRT1C3AR1
SCHEMBL30526285 0.90 FOLH1 (0.49) GNPATSIRT5SIRT6SIRT1C3AR1
SCHEMBL30248962 0.90 FOLH1 (0.55) GNPATSIRT5SIRT6SIRT1FOLH1
SCHEMBL29397145 0.90 SIRT6 (0.56) GNPATSIRT5SIRT6SIRT1FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2198851-B1 Thickened O/W emulsions HENKEL AG & CO KGAA (DE) 2018-03-07 EP disclosed
EP-2370177-B1 NOVEL COSMETIC COMPOSITIONS HAVING HAIR GROWTH INHIBITING EFFECT HENKEL AG & CO KGAA (DE) 2017-11-15 EP disclosed
EP-1852102-B1 Method for manufacturing oil in water emulsions for roll-on applications HENKEL AG & CO KGAA (DE) 2016-10-05 EP disclosed
EP-1803435-B1 Cosmetic sun protection compositions based on lamelliform emulsions HENKEL AG & CO KGAA (DE) 2016-06-08 EP disclosed
EP-2023888-B1 QUICK-DRYING COSMETIC EMULSIONS FOR ROLL-ON APPLICATION HENKEL AG & CO KGAA (DE) 2015-10-07 EP disclosed
WO-2013092080-A1 PERSONAL HYGIENE COMPOSITION WITH IMPROVED SKIN MOISTURE HENKEL AG & CO. KGAA (DE) 2013-06-27 WO disclosed
WO-2013091975-A1 BIOMIMETIC COMPOSITIONS FOR SKIN CLEANSING AND SKIN CARE HENKEL AG & CO. KGAA (DE) 2013-06-27 WO disclosed
EP-2097059-B1 CLEANSING OR CARE PRODUCT HENKEL KGAA (DE) 2012-04-18 EP disclosed
EP-2370177-A2 NOVEL COSMETIC COMPOSITIONS HAVING HAIR GROWTH INHIBITING EFFECT Henkel AG & Co. KGaA (DE) 2011-10-05 EP disclosed
EP-2266529-A2 UV protection cosmetic product Henkel AG & Co. KGaA (DE) 2010-12-29 EP disclosed
EP-1671673-A1 Pigments containing water-in-siliconoil-emulsion for improving the appearance of the skin Henkel Kommanditgesellschaft auf Aktien (DE) 2006-06-21 EP disclosed
WO-2006053688-A1 COSMETIC AND DERMATOLOGICAL PREPARATIONS FOR THE TREATMENT OF MATURE SKIN HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-05-26 WO disclosed
WO-2006042625-A2 COMPOSITIONS WITH INHIBITORS OF THE SYNTHESIS OF PROSTAGLANDIN AND/OR OF LEUKOTRIENE IN CONJUNCTION WITH STIMULATORS OF THE RELEASE OF CUTANEOUS NEUROMEDIATORS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-04-27 WO disclosed
WO-2006042627-A2 COSMETIC AND DERMATOLOGICAL COMPOSITIONS CONTAINING ACTIVE SUBSTANCES FOR IMPROVING SENSORY PERCEPTION HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-04-27 WO disclosed
EP-1634576-A1 DNA repair enzymes and oligopeptides containing cosmetic and dermatological compositions Henkel Kommanditgesellschaft auf Aktien (DE) 2006-03-15 EP disclosed
WO-2006018149-A1 COSMETIC COMPOSITIONS FOR TREATING STRESSED SKIN CONTAINING TAURINE AND LONG-CHAINED FATTY ALCOHOLS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-02-23 WO disclosed
WO-2006018198-A1 COSMETIC AND DERMATOLOGICAL COMPOSITIONS COMPRISING (2-HYDROXYETHYL)UREA HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-02-23 WO disclosed
US-6905690-B2 Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents EXSYMOL S.A.M. (MC) 2005-06-14 US disclosed
US-20040175397-A1 Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents SEGUIN MARIE-CHRISTINE (US) 2004-09-09 US disclosed
US-20030190327-A1 CITRULLINYLARGININE DIPEPTIDE ANALOGS AND THEIR DERMATOLOGICAL USES AS CARE AND TREATMENT AGENTS EXSYMOL S.A.M. (MC) 2003-10-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040175397-A1 Citrullinylarginine dipeptide analogs and their dermatological uses as care and treatment agents ARG1, ARG2, CUTA GNPAT 2303/4885SIRT5 1987/4885SIRT6 1700/4885
US-20030190327-A1 CITRULLINYLARGININE DIPEPTIDE ANALOGS AND THEIR DERMATOLOGICAL USES AS CARE AND TREATMENT AGENTS ARG1, ARG2, ARGLU1 GNPAT 2635/4885SIRT5 2335/4885SIRT6 1977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.