Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747759 | 0.94 | GRM4 (0.40) | GRM4DHODHPOLBERN1HTR7 | |
| SCHEMBL25150811 | 0.82 | KDM4E (0.34) | GRM4POLBMEN1KMT2ASIRT1 | |
| SCHEMBL18284018 | 0.81 | CHRNA7 (0.39) | GRM4POLBHTR7MEN1MAPT | |
| SCHEMBL25150792 | 0.80 | GRM4 (0.34) | GRM4POLBMEN1KMT2A | |
| SCHEMBL30186793 | 0.76 | FPR2 (0.46) | MAPT | |
| SCHEMBL30398712 | 0.76 | FPR2 (0.49) | MEN1MAPTKMT2A | |
| SCHEMBL18296156 | 0.76 | FPR2 (0.49) | MEN1MAPTKMT2A | |
| SCHEMBL31559661 | 0.75 | PSMB1 (0.36) | DHODHKMT2A | |
| SCHEMBL15263578 | 0.74 | MPI (0.52) | GRM4MEN1MAPTKMT2AGRM1 | |
| SCHEMBL18939739 | 0.74 | HTR7 (0.49) | HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015161011-A1 | BENZAMIDE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-10-22 | — | — | WO | disclosed |