Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059163 | 0.82 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3LMNAPIK3CD | |
| SCHEMBL12209608 | 0.80 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3PIK3CD | |
| SCHEMBL15088411 | 0.79 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3KCNH2LMNA | |
| SCHEMBL27753862 | 0.78 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3KCNH2OPRD1 | |
| SCHEMBL30804747 | 0.75 | TGFBR1 (0.49) | — | |
| SCHEMBL3809371 | 0.75 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3KCNH2OPRD1 | |
| SCHEMBL1559121 | 0.75 | CYP2C19 (0.38) | LMNAMAPTHTTPIK3CD | |
| SCHEMBL5599731 | 0.75 | HSD11B1 (0.46) | OPRD1PIK3CD | |
| SCHEMBL4634860 | 0.75 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3KCNH2OPRD1 | |
| SCHEMBL1004218 | 0.74 | LMNA (0.65) | SLC6A4SLC6A2SLC6A3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015161011-A1 | BENZAMIDE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-10-22 | — | — | WO | disclosed |