Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13434090 | 0.89 | L3MBTL1 (0.51) | HSD11B1CHRM2CHRM3L3MBTL1CCR5 | |
| SCHEMBL4139952 | 0.84 | L3MBTL1 (0.62) | HSD11B1L3MBTL1CCR5ALDH1A1AGER | |
| SCHEMBL4634860 | 0.82 | SLC6A4 (0.57) | HSD11B1CHRM2CHRM3L3MBTL1KDM5A | |
| SCHEMBL30804747 | 0.80 | TGFBR1 (0.49) | HSD11B1CCR5HPGD | |
| SCHEMBL13431573 | 0.78 | HSD11B1 (0.78) | HSD11B1 | |
| SCHEMBL6119943 | 0.77 | PIK3CD (0.51) | HSD11B1L3MBTL1PIK3CDOPRM1 | |
| SCHEMBL13434087 | 0.77 | HPGD (0.49) | L3MBTL1ALDH1A1HPGDKDM5A | |
| SCHEMBL1559121 | 0.76 | CYP2C19 (0.38) | HSD11B1CHRM2CHRM3SLC6A9ALDH1A1 | |
| SCHEMBL13434159 | 0.76 | SLC6A4 (0.58) | HSD11B1CHRM2CHRM3CCR5ALDH1A1 | |
| SCHEMBL562040 | 0.76 | NPC1 (0.45) | HSD11B1SLC6A9ALDH1A1HPGDNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740584-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105802-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |