Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | MBTPS1 | Q14703 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13434090 | 0.89 | L3MBTL1 (0.51) | OPRD1OPRM1KDM5AHSD11B1CHRM2 | |
| Hydrochloric Acid SCHEMBL7136730 | 0.87 | SLC6A4 (0.71) | SLC6A4KCNH2SLC6A2SLC6A3OPRD1 | |
| SCHEMBL4139952 | 0.84 | L3MBTL1 (0.62) | SLC6A4SLC6A2HSD11B1L3MBTL1 | |
| SCHEMBL5599731 | 0.82 | HSD11B1 (0.46) | OPRD1OPRM1KDM5AHSD11B1CHRM2 | |
| SCHEMBL3809371 | 0.80 | SLC6A4 (0.51) | SLC6A4KCNH2SLC6A2SLC6A3OPRD1 | |
| SCHEMBL4027887 | 0.79 | L3MBTL1 (0.57) | SLC6A4KCNH2SLC6A2SLC6A3L3MBTL1 | |
| SCHEMBL27753862 | 0.79 | SLC6A4 (0.51) | SLC6A4KCNH2SLC6A2SLC6A3OPRD1 | |
| SCHEMBL1290745 | 0.78 | SLC6A4 (0.42) | SLC6A4KCNH2SLC6A2SLC6A3OPRD1 | |
| SCHEMBL16655923 | 0.77 | NPC1 (0.56) | SLC6A4KCNH2SLC6A2SLC6A3L3MBTL1 | |
| SCHEMBL13434087 | 0.77 | HPGD (0.49) | SLC6A4KCNH2KDM5AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638933-B1 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2008-06-11 | — | — | EP | claimed |