Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PNLIP | P16233 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364360 | 0.83 | LMNA (0.43) | LMNAPNLIPTDP1CCNCCDK8 | |
| SCHEMBL17185349 | 0.82 | HTR2A (0.42) | LMNAPNLIPTDP1CCNCCDK8 | |
| SCHEMBL17185501 | 0.81 | ALDH1A1 (0.40) | LMNATDP1KMT2AHPGDL3MBTL1 | |
| SCHEMBL17996051 | 0.80 | P2RX3 (0.55) | LMNATDP1ABL1P2RX3SLC6A4 | |
| SCHEMBL4449413 | 0.78 | PTGER4 (0.57) | LMNAPNLIPTDP1ABL1HPGD | |
| SCHEMBL17184697 | 0.78 | KDM4E (0.51) | KMT2AHPGDMAPT | |
| SCHEMBL363951 | 0.75 | GAA (0.46) | LMNAABL1KMT2AHPGDNPC1 | |
| SCHEMBL1462096 | 0.74 | ABL1 (0.61) | LMNAABL1KMT2AHPGDSLC6A4 | |
| SCHEMBL5357436 | 0.74 | TDP1 (0.53) | LMNAPNLIPTDP1ABL1KMT2A | |
| SCHEMBL19993672 | 0.74 | MAPT (0.42) | LMNATDP1HPGDSLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015161011-A1 | BENZAMIDE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-10-22 | — | — | WO | disclosed |