Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17177787 | 0.78 | TGFBR1 (0.34) | KDRTGFBR1MAPK14JAK2JAK1 | |
| SCHEMBL18811521 | 0.75 | JAK2 (0.32) | KDRTGFBR1MAPK14JAK2JAK1 | |
| SCHEMBL19819855 | 0.74 | KDM5A (0.33) | KDRTGFBR1MAPK14JAK2JAK1 | |
| SCHEMBL21089574 | 0.73 | — | — | |
| SCHEMBL4032880 | 0.72 | ALDH1A1 (0.37) | — | |
| SCHEMBL22979883 | 0.71 | NOTUM (0.38) | JAK2JAK1TYK2 | |
| SCHEMBL25237034 | 0.70 | LRRK2 (0.34) | LRRK2 | |
| SCHEMBL22979405 | 0.68 | KDM4E (0.36) | JAK2JAK1TYK2CNR2 | |
| SCHEMBL22979644 | 0.67 | TSHR (0.40) | — | |
| SCHEMBL16825437 | 0.67 | DRD2 (0.36) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015158427-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |