SCHEMBL17200652

SCHEMBL17200652

Cc1cc(F)c(Nc2c(-c3ccc(F)cc3Cl)c(C)nn2C)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.38
SLC34A1 Q06495 5/20 0.38
P2RX7 Q99572 2/20 0.35
IGF1R P08069 2/20 0.34
CYP3A4 P08684 2/20 0.32
CRHR1 P34998 1/20 0.32
PTPN11 Q06124 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17200657 0.95 HSD11B1 (0.40) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL17164758 0.94 HSD11B1 (0.40) HSD11B1SLC34A1P2RX7IGF1RCRHR1
SCHEMBL168744 0.93 SLC34A1 (0.41) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL170613 0.92 HSD11B1 (0.39) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL17200645 0.90 MAPT (0.36) HSD11B1SLC34A1P2RX7
SCHEMBL17200658 0.90 HSD11B1 (0.36) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL29368805 0.90 HSD11B1 (0.40) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL173677 0.90 HSD11B1 (0.40) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL173410 0.90 SLC34A1 (0.41) HSD11B1SLC34A1P2RX7IGF1RCYP3A4
SCHEMBL173545 0.89 HSD11B1 (0.42) HSD11B1SLC34A1P2RX7IGF1RPTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9464056-B2 Fungicidal 4-methylanilino pyrazoles E I DU PONT DE NEMOURS AND COMPANY (US) 2016-10-11 US claimed
EP-2864293-B1 FUNGICIDAL 4-METHYLANILINO PYRAZOLES DU PONT (US) 2016-04-27 EP claimed
US-20150307456-A1 FUNGICIDAL 4-METHYLANILINO PYRAZOLES FMC CORPORATION 2015-10-29 US claimed
US-9888688-B2 Tetrazolinone compounds and applications thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-02-13 US disclosed
US-9888688-B2 Tetrazolinone compounds and applications thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-02-13 US disclosed
US-9781933-B2 Tetrazolinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-10-10 US disclosed
US-9781933-B2 Tetrazolinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-10-10 US disclosed
US-9464056-B2 Fungicidal 4-methylanilino pyrazoles E I DU PONT DE NEMOURS AND COMPANY (US) 2016-10-11 US disclosed
US-20160174558-A1 TETRAZOLINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-06-23 US disclosed
US-20160174558-A1 TETRAZOLINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-06-23 US disclosed
US-20160150787-A1 TETRAZOLINONE COMPOUNDS AND APPLICATIONS THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-06-02 US disclosed
US-20160150787-A1 TETRAZOLINONE COMPOUNDS AND APPLICATIONS THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-06-02 US disclosed
EP-3020715-A1 TETRAZOLINONE COMPOUND AND USE THEREOF Sumitomo Chemical Company Limited (JP) 2016-05-18 EP disclosed
EP-2864293-B1 FUNGICIDAL 4-METHYLANILINO PYRAZOLES DU PONT (US) 2016-04-27 EP disclosed
US-20150307456-A1 FUNGICIDAL 4-METHYLANILINO PYRAZOLES FMC CORPORATION 2015-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160174558-A1 TETRAZOLINONE COMPOUND AND USE THEREOF MT-CO1, KCNA5, MT-CO2 HSD11B1 2693/4885SLC34A1 2825/4885P2RX7 477/4885
US-20160150787-A1 TETRAZOLINONE COMPOUNDS AND APPLICATIONS THEREOF SOD1, UQCRB, MT-CO1 HSD11B1 1971/4885SLC34A1 4174/4885P2RX7 814/4885
US-20150307456-A1 FUNGICIDAL 4-METHYLANILINO PYRAZOLES CYP2F1, CYP1B1, CYP4B1 HSD11B1 171/4885SLC34A1 1978/4885P2RX7 1520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.