Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827463 | 0.95 | CA2 (0.62) | CA2PTGS2PTGS1PTPN1EGFR | |
| SCHEMBL7827465 | 0.95 | CA2 (0.62) | CA2PTGS2PTGS1PTPN1EGFR | |
| SCHEMBL7823200 | 0.92 | CA2 (0.49) | CA2PTGS2PTGS1PTPN1EGFR | |
| SCHEMBL7823202 | 0.92 | CA2 (0.49) | CA2PTGS2PTGS1PTPN1EGFR | |
| SCHEMBL7829424 | 0.89 | ALDH1A1 (0.58) | CA2PTGS2PTGS1CA1ALDH1A1 | |
| SCHEMBL7829422 | 0.89 | ALDH1A1 (0.58) | CA2PTGS2PTGS1CA1ALDH1A1 | |
| SCHEMBL7814593 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTKDM4ECYP3A4 | |
| SCHEMBL7814591 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTKDM4ECYP3A4 | |
| SCHEMBL22502063 | 0.84 | ALDH1A1 (0.53) | CA2PTPN1EGFRLCKCA1 | |
| SCHEMBL7821779 | 0.82 | PIM1 (0.53) | PTGS2PTGS1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170306386-A1 | YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE | THE UNIVERSITY OF CHICAGO (US) | 2017-10-26 | — | — | US | disclosed |
| US-20130005608-A1 | YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE | THE UNIVERSITY OF CHICAGO (US) | 2013-01-03 | — | — | US | disclosed |
| EP-1392849-B2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIV CHICAGO (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-2319936-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-1392849-B1 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIV CHICAGO (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1793001-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1392849-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | THE UNIVERSITY OF CHICAGO (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002065136-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIVERSITY OF CHICAGO (US) | 2002-08-22 | — | — | WO | disclosed |