Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425861 | 0.65 | DAO (0.48) | RORCDAOALDH1A1HPGDTSHR | |
| SCHEMBL17206345 | 0.65 | RORC (0.38) | RORCDAOALDH1A1HPGDTSHR | |
| SCHEMBL2185504 | 0.64 | ALDH1A1 (0.41) | RORCDAOALDH1A1HPGDTSHR | |
| SCHEMBL4025384 | 0.62 | RORC (0.35) | RORCDAOALDH1A1TSHRKDM4E | |
| SCHEMBL27756804 | 0.61 | RORC (0.44) | RORCALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL3119596 | 0.61 | PIK3CD (0.56) | ALDH1A1KDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL5104631 | 0.61 | PKM (0.52) | DAOALDH1A1HPGDTSHRBCL2L1 | |
| SCHEMBL3093344 | 0.60 | DAO (0.65) | DAOALDH1A1HPGDBCL2L1KDM4E | |
| SCHEMBL3903860 | 0.59 | MAPT (0.39) | DAOALDH1A1HPGDTSHRBCL2L1 | |
| SCHEMBL12917930 | 0.58 | DAO (0.42) | DAOALDH1A1HPGDTSHRBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140309-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | Grünenthal GmbH (DE) | 2017-03-15 | — | — | EP | disclosed |
| WO-2015161928-A1 | 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I | Grünenthal GmbH (DE) | 2015-10-29 | — | — | WO | disclosed |