Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364130 | 0.82 | GPR35 (0.44) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL102004 | 0.81 | ALDH1A1 (0.40) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL3057931 | 0.79 | PKM (0.37) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL4547877 | 0.79 | ALDH1A1 (0.55) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL3093344 | 0.79 | DAO (0.65) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL7965972 | 0.79 | IKBKB (0.42) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL243572 | 0.77 | KDM4E (0.42) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL12104573 | 0.77 | PKM (0.48) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL4971298 | 0.77 | PKM (0.44) | PKMNPSR1RXFP1DAOALDH1A1 | |
| SCHEMBL12917930 | 0.77 | DAO (0.42) | PKMNPSR1RXFP1DAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12410152-B2 | Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof | PROXYGEN GMBH (AT) | 2025-09-09 | — | — | US | disclosed |
| WO-2024054624-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-03-14 | — | — | WO | disclosed |
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-12-12 | — | — | US | disclosed |
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-12-12 | — | — | US | disclosed |
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-08-01 | — | — | US | disclosed |
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-08-01 | — | — | US | disclosed |
| US-20230124700-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2023-04-20 | — | — | US | disclosed |
| US-20230124700-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2023-04-20 | — | — | US | disclosed |
| EP-4045142-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CeMM - Forschungszentrum für Molekulare Medizin GmbH (AT) | 2022-08-24 | — | — | EP | disclosed |
| US-11325899-B2 | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-05-10 | — | — | US | disclosed |
| US-6924302-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-04-22 | — | — | US | disclosed |
| EP-1355889-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6559140-B2 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | ABBOTT LABORATORIES | 2003-05-06 | — | — | US | disclosed |
| WO-2002057240-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MC NEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
| US-20010049367-A1 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | ABBVIE INC. | 2001-12-06 | — | — | US | disclosed |
| WO-2001066534-A2 | CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |
| US-5840917-A | ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0852498-A1 | PHOSPHORYLAMIDES, THEIR PREPARATION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997011705-A1 | PHOSPHORYLAMIDES, THEIR PREPARATION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049367-A1 | Cyclic and bicyclic diamino histamine-3 receptor antagonists | HRH4, HRH2, HRH3 | PKM 3440/4885NPSR1 120/4885RXFP1 530/4885 |
| US-12410152-B2 | Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof | CUL1, CUL5, CUL3 | PKM 1673/4885NPSR1 4534/4885RXFP1 3952/4885 |
| US-20230124700-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CUL1, CUL5, CUL3 | PKM 1673/4885NPSR1 4534/4885RXFP1 3952/4885 |
| US-11712438-B2 | Phenyl derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | PKM 1961/4885NPSR1 295/4885RXFP1 135/4885 |
| US-11839613-B2 | Pyrimidine derivatives as PGE2 receptor modulators | PTGER1, PTGER4, PTGER2 | PKM 2638/4885NPSR1 375/4885RXFP1 286/4885 |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | MAP2K2, PRKDC, MAP2K3 | PKM 896/4885NPSR1 3939/4885RXFP1 4272/4885 |
| US-11325899-B2 | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators | PTGER4, PTGER1, PTGER2 | PKM 2680/4885NPSR1 356/4885RXFP1 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.