Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.78 |
| ▸ | MAPT | P10636 | 9/20 | 0.78 |
| ▸ | NPC1 | O15118 | 8/20 | 0.78 |
| ▸ | RAB9A | P51151 | 8/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.78 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.78 |
| ▸ | RELA | Q04206 | 3/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208122 | 0.87 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL15778999 | 0.87 | SMN1; SMN2 (0.75) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL15786670 | 0.76 | RAB9A (0.67) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL3979426 | 0.71 | HPGD (0.62) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL20892324 | 0.69 | HPGD (0.55) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL20787902 | 0.69 | NPC1 (0.57) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL23334741 | 0.68 | TP53 (0.57) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL13545859 | 0.66 | KMT2A (0.57) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL23335496 | 0.66 | TP53 (0.51) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL22336162 | 0.63 | HPGD (0.51) | SMN1; SMN2MAPTNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190092720-A1 | FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION | BARUCH S BLUMBERG INST (US) | 2019-03-28 | — | — | US | disclosed |
| US-20150307443-A1 | FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION | BARUCH S BLUMBERG INST (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307443-A1 | FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION | BARUCH S BLUMBERG INST (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190092720-A1 | FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION | HAVCR2, PHB2, PHB1 | SMN1; SMN2 4643/4885MAPT 4291/4885NPC1 539/4885 |
| US-20150307443-A1 | FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION | HAVCR2, PHB2, PHB1 | SMN1; SMN2 4573/4885MAPT 4315/4885NPC1 535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.