SCHEMBL1720975

SCHEMBL1720975

NCc1ccc(-c2ccccc2)nc1

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 13/20 0.59
CYP11B2 P19099 13/20 0.59
TAAR1 Q96RJ0 1/20 0.54
CYP3A4 P08684 1/20 0.51
LDHA P00338 1/20 0.47
LOXL2 Q9Y4K0 1/20 0.44
HPGDS O60760 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP2A6 P11509 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30083539 1.00 CYP11B1 (0.59) CYP11B1CYP11B2TAAR1CYP3A4LDHA
Hydrochloric Acid SCHEMBL5010818 0.98 CYP11B1 (0.57) CYP11B1CYP11B2TAAR1CYP3A4LDHA
SCHEMBL2414535 0.85 CYP11B1 (0.56) CYP11B1CYP11B2TAAR1CYP3A4LOXL2
SCHEMBL351473 0.83 LOXL2 (0.46) CYP11B1CYP11B2TAAR1LOXL2CYP2A6
SCHEMBL14355099 0.82 CYP11B1 (0.57) CYP11B1CYP11B2CYP3A4LOXL2CYP2A6
SCHEMBL23929936 0.82 LOXL2 (0.64) CYP11B1CYP11B2CYP3A4LOXL2CYP2A6
SCHEMBL30175280 0.82 LOXL2 (0.64) CYP11B1CYP11B2CYP3A4LOXL2CYP2A6
SCHEMBL30175278 0.82 LOXL2 (0.64) CYP11B1CYP11B2CYP3A4LOXL2CYP2A6
SCHEMBL6673316 0.81 AURKA (0.54) CYP11B1CYP11B2TAAR1CYP3A4NPC1
Hydrochloric Acid SCHEMBL31716140 0.81 CYP11B1 (0.54) CYP11B1CYP11B2CYP3A4LOXL2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240383900-A1 SUBSTITUTED PYRAZOLO [1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE Carrick Therapeutics Limited (IE) 2024-11-21 US disclosed
CN-117940427-A Substituted pyrazolo [1,5-a ] pyrimidine-7-amine compounds as CDK inhibitors and therapeutic uses thereof 卡里克治疗有限公司 2024-04-26 CN disclosed
EP-4355426-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE Carrick Therapeutics Limited (IE) 2024-04-24 EP disclosed
WO-2023158221-A1 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING ANTICANCER AGENT AND NOVEL COMPOUND HAVING INHIBITORY ACTIVITY WITH RESPECT TO PROSTAGLANDIN E2 RECEPTORS 주식회사 카나프테라퓨틱스 2023-08-24 WO disclosed
WO-2022263604-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE Carrick Therapeutics Limited (IE) 2022-12-22 WO disclosed
EP-2810944-A1 HETEROCYCLIC COMPOUND HAVING ANTI-HIV ACTIVITY Toyama Chemical Co., Ltd. (JP) 2014-12-10 EP disclosed
EP-2406263-B1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF CENTRE NAT RECH SCIENT (FR) 2013-09-25 EP disclosed
US-20120184557-A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-07-19 US disclosed
EP-2406263-A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF Centre National de la Recherche Scientifique (C.N.R.S.) (FR) 2012-01-18 EP disclosed
WO-2010103486-A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-09-16 WO disclosed
WO-2010103486-A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-09-16 WO disclosed
WO-2010103473-A1 METHOD OF TREATMENT OF POLYCYSTIC DISEASES AND CHRONIC LYMPHOCYTIC LEUKEMIA CHU DE BREST (FR) 2010-09-16 WO disclosed
US-20060287378-A1 Novel pyrroles and imidazoles WARNER-LAMBERT COMPANY LLC 2006-12-21 US disclosed
US-20050239857-A1 Novel imidazoles BOLTON GARY L 2005-10-27 US disclosed
EP-0784612-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-23 EP disclosed
WO-1996010559-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287378-A1 Novel pyrroles and imidazoles PPIP5K2, PPIE, PPOX CYP11B1 331/4885CYP11B2 237/4885TAAR1 2250/4885
US-20120184557-A1 PYRAZOLO[1,5-A]-1,3,5-TRIAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AOC3, CBR3, RTN3 CYP11B1 1567/4885CYP11B2 1407/4885TAAR1 261/4885
US-20050239857-A1 Novel imidazoles HMGCR, HMGB2, HMGB3 CYP11B1 5/4885CYP11B2 4/4885TAAR1 3974/4885
US-20240383900-A1 SUBSTITUTED PYRAZOLO [1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE CDK3, CDK1, CDK2 CYP11B1 3042/4885CYP11B2 2911/4885TAAR1 3817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.