Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA1A | P0DMV8 | 7/20 | 0.81 |
| ▸ | PTPN7 | P35236 | 7/20 | 0.81 |
| ▸ | MASP2 | O00187 | 3/20 | 0.81 |
| ▸ | CDC25B | P30305 | 2/20 | 0.81 |
| ▸ | CD44 | P16070 | 1/20 | 0.81 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.81 |
| ▸ | MSN | P26038 | 1/20 | 0.81 |
| ▸ | AKT1 | P31749 | 1/20 | 0.81 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.74 |
| ▸ | POLB | P06746 | 9/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | GAA | P10253 | 4/20 | 0.74 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.74 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.74 |
| ▸ | NSD2 | O96028 | 2/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | ALPL | P05186 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808722 | 0.90 | PTPN7 (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL29415450 | 0.90 | PTPN7 (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL16706084 | 0.85 | POLB (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL29954899 | 0.85 | POLB (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL23949487 | 0.84 | KMT2A (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL26458981 | 0.84 | KMT2A (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL23950001 | 0.82 | KMT2A (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL23949935 | 0.80 | KMT2A (1.00) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL23949811 | 0.79 | MAPT (0.81) | HSPA1APTPN7MASP2CDC25BCD44 | |
| SCHEMBL681674 | 0.79 | MAPT (0.81) | HSPA1APTPN7MASP2CDC25BCD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CAMKK2 | HSPA1A 4301/4885PTPN7 1125/4885MASP2 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.