SCHEMBL2808722

SCHEMBL2808722

O=C(O)c1ccc2c(c1)C1C=CCC1C(C(=O)O)N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN7 P35236 13/20 1.00
HSPA1A P0DMV8 12/20 1.00
MASP2 O00187 3/20 1.00
CDC25B P30305 2/20 1.00
CD44 P16070 2/20 1.00
MSN P26038 2/20 1.00
EZH2 Q15910 2/20 1.00
PTPN1 P18031 1/20 1.00
AKT1 P31749 1/20 1.00
POLB P06746 9/20 0.81
KMT2A Q03164 9/20 0.81
ALDH1A1 P00352 6/20 0.81
L3MBTL1 Q9Y468 6/20 0.81
GAA P10253 5/20 0.81
MCL1 Q07820 2/20 0.81
APOBEC3A P31941 2/20 0.81
APOBEC3G Q9HC16 2/20 0.81
USP2 O75604 2/20 0.81
NSD2 O96028 2/20 0.81
ALPL P05186 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415450 1.00 PTPN7 (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL16706084 0.90 POLB (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL29954899 0.90 POLB (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL17211738 0.90 HSPA1A (0.81) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL16706087 0.84 PTPN7 (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL3610631 0.84 CDC25B (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL2116528 0.84 PTPN7 (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL13186581 0.84 PTPN7 (0.73) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL23949487 0.84 KMT2A (1.00) PTPN7HSPA1AMASP2CDC25BCD44
SCHEMBL2116204 0.84 PTPN7 (0.85) PTPN7HSPA1AMASP2CDC25BCD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
US-20230145071-A1 MASP-2 INHIBITORS AND METHODS OF USE OMEROS CORPORATION 2023-05-11 US disclosed
US-20230145071-A1 MASP-2 INHIBITORS AND METHODS OF USE OMEROS CORPORATION 2023-05-11 US disclosed
US-11584714-B2 MASP-2 inhibitors and methods of use OMEROS CORPORATION (US) 2023-02-21 US disclosed
US-11559474-B2 Hair lightening compositions and methods of use L'OREAL (FR) 2023-01-24 US disclosed
WO-2018119500-A1 VISCOELASTIC COSMETIC COMPOSITIONS L'OREAL (FR) 2018-07-05 WO disclosed
EP-2931280-B1 METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 PHUSIS THERAPEUTICS INC (US) 2018-02-14 EP disclosed
US-9340532-B2 Methods and compositions for inhibiting CNKSR1 PHUSIS THERAPEUTICS, INC. (US) 2016-05-17 US disclosed
US-20150307482-A1 METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 PHUSIS THERAPEUTICS, INC. (US) 2015-10-29 US disclosed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US disclosed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US disclosed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US disclosed
US-20090203726-A1 SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIBACTERIAL AGENTS MAXTHERA INC. (US) 2009-08-13 US disclosed
US-20090203726-A1 SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIBACTERIAL AGENTS MAXTHERA INC. (US) 2009-08-13 US disclosed
WO-2009073550-A2 SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIBACTERIAL AGENTS MAXTHERA, INC. (US) 2009-06-11 WO disclosed
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION L'OREAL (FR) 2009-01-29 US disclosed
US-20070072875-A1 ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE MCMASTER BRIAN 2007-03-29 US disclosed
US-20070072875-A1 ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE MCMASTER BRIAN 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11584714-B2 MASP-2 inhibitors and methods of use MASP2, METAP2, SPINT2 PTPN7 1542/4885HSPA1A 3544/4885MASP2 1/4885
US-20230145071-A1 MASP-2 INHIBITORS AND METHODS OF USE MASP2, METAP2, SPINT2 PTPN7 1542/4885HSPA1A 3544/4885MASP2 1/4885
US-20150307482-A1 METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 CNKSR1, CAMKK1, CAMKK2 PTPN7 1125/4885HSPA1A 4301/4885MASP2 3217/4885
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 PTPN7 1180/4885HSPA1A 1414/4885MASP2 3934/4885
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION CUTA, SYMPK, TPRKB PTPN7 1673/4885HSPA1A 3324/4885MASP2 1612/4885
US-20070072875-A1 ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF USE CCL11, CCL5, CCL2 PTPN7 751/4885HSPA1A 895/4885MASP2 174/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA PTPN7 1432/4885HSPA1A 2508/4885MASP2 4350/4885
US-20090203726-A1 SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIBACTERIAL AGENTS NISCH, NDUFS3, SDHA PTPN7 3898/4885HSPA1A 581/4885MASP2 610/4885
US-11559474-B2 Hair lightening compositions and methods of use TYR, ALAD, CYBA PTPN7 1408/4885HSPA1A 3253/4885MASP2 4760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.