Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.37 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14137074 | 0.89 | CYP26A1 (0.46) | CYP24A1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL14062029 | 0.87 | CYP24A1 (0.49) | METAP1CYP24A1CYP27A1CYP26A1SMN1; SMN2 | |
| SCHEMBL14062034 | 0.84 | CYP26A1 (0.39) | CYP24A1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL14137073 | 0.83 | DRD2 (0.44) | CYP24A1CYP27A1CYP26A1ACHE | |
| SCHEMBL13954369 | 0.83 | ALDH1A1 (0.36) | PARP10PARP11METAP1CYP24A1CYP27A1 | |
| SCHEMBL14062072 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AGAARAB9A | |
| SCHEMBL2472482 | 0.79 | CYP24A1 (0.50) | METAP1CYP24A1CYP27A1CYP26A1ACHE | |
| SCHEMBL17195438 | 0.75 | CYP24A1 (0.46) | METAP1CYP24A1CYP27A1CYP26A1ACHE | |
| SCHEMBL14137075 | 0.73 | DGAT1 (0.57) | MEN1MAPTKMT2ARAB9ALMNA | |
| SCHEMBL17211829 | 0.73 | CYP24A1 (0.44) | METAP1CYP24A1CYP27A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242929-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | GlaxoSmith Kline Intellectual Property (No.2) Limited (GB) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | DGAT1, DGAT2, LCAT | PARP10 1366/4885PARP11 1513/4885METAP1 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.