Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17220053 | 1.00 | MEN1 (0.35) | MEN1KMT2AHSD11B1EPHX2GAA | |
| SCHEMBL17220206 | 0.91 | L3MBTL1 (0.36) | MEN1KMT2AEPHX2POLBALDH1A1 | |
| SCHEMBL17220204 | 0.91 | L3MBTL1 (0.36) | MEN1KMT2AEPHX2POLBALDH1A1 | |
| SCHEMBL17219967 | 0.80 | HSD11B1 (0.41) | MEN1KMT2AHSD11B1EPHX2GAA | |
| SCHEMBL4352564 | 0.79 | MEN1 (0.39) | MEN1KMT2AHSD11B1GAACCR6 | |
| SCHEMBL17220290 | 0.79 | ALDH1A1 (0.40) | MEN1KMT2AEPHX2CCR6POLB | |
| SCHEMBL1535994 | 0.78 | MEN1 (0.37) | MEN1KMT2AHSD11B1GAACCR6 | |
| SCHEMBL17220417 | 0.77 | P2RX7 (0.41) | MEN1KMT2AHSD11B1CCR6ALDH1A1 | |
| SCHEMBL12035146 | 0.77 | JAK1 (0.36) | KMT2AHSD11B1EPHX2ALDH1A1LMNA | |
| SCHEMBL12033012 | 0.77 | JAK1 (0.36) | KMT2AHSD11B1EPHX2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299821-B1 | TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2015-11-04 | — | — | EP | disclosed |