Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.58 |
| ▸ | PLAU | P00749 | 3/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17221501 | 1.00 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CPLAUPTK2 | |
| SCHEMBL31600623 | 0.79 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CPLAUKDM4E | |
| SCHEMBL619591 | 0.79 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CPLAUKDM4E | |
| SCHEMBL619590 | 0.79 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CPLAUKDM4E | |
| SCHEMBL1354527 | 0.75 | NOS3 (0.39) | ADRA2AADRA2BADRA2CPLAUL3MBTL1 | |
| SCHEMBL1354526 | 0.75 | NOS3 (0.39) | ADRA2AADRA2BADRA2CPLAUL3MBTL1 | |
| SCHEMBL2493594 | 0.73 | ALDH1A1 (0.34) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL2493593 | 0.73 | ALDH1A1 (0.34) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL15562694 | 0.73 | ALDH1A1 (0.34) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16909561 | 0.71 | MKNK1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695166-B2 | Pyrazolopyridine pyrazolopyrimidine and related compounds | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| WO-2015171527-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2015-11-12 | — | — | WO | disclosed |
| US-20150315198-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315198-A1 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS | TPMT, DPYD, XDH | ADRA2A 1327/4885ADRA2B 1212/4885ADRA2C 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.