Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11650660 | 0.87 | TAS1R3 (0.40) | TAS1R3TAS1R1ALOX15LMNATSHR | |
| SCHEMBL4406229 | 0.84 | TSHR (0.48) | FBP1ALDH1A1TDP1ALOX15TSHR | |
| SCHEMBL17230083 | 0.81 | TAS1R3 (0.38) | TAS1R3TAS1R1ALOX15LMNATSHR | |
| SCHEMBL29505096 | 0.79 | ALDH1A1 (0.53) | FBP1ALDH1A1TDP1TLR7LMNA | |
| SCHEMBL11042019 | 0.79 | ALDH1A1 (0.53) | FBP1ALDH1A1TDP1TLR7LMNA | |
| Hydrochloric Acid SCHEMBL17493635 | 0.78 | ALDH1A1 (0.52) | FBP1ALDH1A1TDP1TLR7LMNA | |
| SCHEMBL3347914 | 0.77 | ALDH1A1 (0.46) | FBP1ALDH1A1TDP1LMNATSHR | |
| SCHEMBL664342 | 0.75 | ALDH1A1 (0.44) | FBP1ALDH1A1TDP1LMNATSHR | |
| Hydrochloric Acid SCHEMBL10917756 | 0.75 | ALDH1A1 (0.44) | FBP1ALDH1A1TDP1LMNATSHR | |
| SCHEMBL11855106 | 0.74 | GRIN2D (0.53) | ALDH1A1TDP1LMNATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137470-B1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2021-04-07 | — | — | EP | disclosed |
| US-9902730-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2018-02-27 | — | — | US | disclosed |
| EP-3137470-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | Novartis AG (CH) | 2017-03-08 | — | — | EP | disclosed |
| US-20170057968-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2017-03-02 | — | — | US | disclosed |
| WO-2015168269-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2015-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057968-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | TLR7, TLR3, TLR1 | FBP1 3389/4885TAS1R3 555/4885TAS1R1 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.